TIGIT Inhibitors Market Poised for Strong Growth Through 2034, Driven by Expanding Immuno-Oncology Pipeline | DelveInsight

The market for TIGIT inhibitors is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with NSCLC, RCC, colorectal cancer, lung cancer, and many more indications; the growing awareness of TIGIT inhibitors; and the increasing number of emerging drugs such as domvanalimab (Arcus Biosciences and Gilead Sciences), rilvegostomig (AstraZeneca, Compugen, and Daiichi Sankyo), Casdozokitug (CHS-388) (Coherus Biosciences), COM902 (Compugen), and others. 

LAS VEGAS, Feb. 2, 2026 /PRNewswire/ -- DelveInsight's TIGIT Inhibitors Market Size, Target Population, Competitive Landscape & Market Forecast report includes a comprehensive understanding of current treatment practices, addressable patient population, which includes top indications such as Renal cell carcinoma, Non-small cell lung cancer, Colorectal cancer, Head and neck squamous cell carcinoma, Melanoma, Esophageal squamous cell carcinoma, Endometrial cancer, Hepatocellular carcinoma, and others. The selected indications are based on approved therapies and ongoing pipeline activity. The report also provides insights into the emerging TIGIT inhibitors, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into leading markets (the US, EU4, UK, and Japan).

Key Takeaways from the TIGIT Inhibitors Market Report

Discover what is the current TIGIT inhibitors market size and expected growth by 2034 @ https://www.delveinsight.com/sample-request/tigit-inhibitors-market-forecast?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr

Key Factors Driving the TIGIT Inhibitors Market 

TIGIT Inhibitors Market Analysis

Learn more about who are the leading companies in TIGIT inhibitors @ TIGIT Inhibitors Analysis

TIGIT Inhibitors Competitive Landscape

Some of the potential products in the TIGIT inhibitor clinical trial landscape include domvanalimab (Arcus Biosciences and Gilead Sciences), rilvegostomig (AstraZeneca, Compugen, and Daiichi Sankyo), Casdozokitug (CHS-388) (Coherus Biosciences), COM902 (Compugen), and others.

Arcus Biosciences and Gilead Sciences' Domvanalimab is a humanized IgG1 monoclonal antibody directed against the immune checkpoint receptor TIGIT. By preventing TIGIT from binding to its ligands CD112 and CD155, it augments CD226-driven signaling in NK cells and CD8⁺ T cells, leading to enhanced anti-tumor immune activity. Domvanalimab is currently being investigated in non-small cell lung cancer and upper gastrointestinal malignancies.

AstraZeneca, Compugen, and Daiichi Sankyo's Rilvegostomig is a bispecific antibody that simultaneously targets PD-1 and TIGIT. By concurrently blocking PD-1 interactions with PD-L1/PD-L2 and TIGIT interactions with CD112/CD155, it reinvigorates T-cell activity and boosts CD226-mediated signaling in NK cells and CD8⁺ T cells, thereby strengthening anti-tumor immune responses. Rilvegostomig is under clinical evaluation in non-small cell lung cancer, head and neck squamous cell carcinoma, biliary tract cancer, and other solid tumors.

The anticipated launch of these emerging therapies are poised to transform the TIGIT inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the TIGIT inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.

To know more about which TIGIT inhibitor candidates are in late-stage clinical trials, visit @ TIGIT Inhibitors Treatment 

Recent Developments in the TIGIT Inhibitors Market

What are TIGIT Inhibitors?

TIGIT inhibitors are a class of cancer immunotherapy agents designed to enhance the body's immune response against tumors by targeting TIGIT (T cell immunoreceptor with Ig and ITIM domains), an immune checkpoint receptor expressed on T cells and natural killer (NK) cells. TIGIT interacts with ligands such as CD155 (PVR) on tumor cells and antigen-presenting cells to deliver inhibitory signals that suppress immune cell activation and cytokine production, enabling tumors to evade immune surveillance. By blocking the TIGIT pathway, TIGIT inhibitors restore T-cell and NK-cell function, promote antitumor immunity, and can synergize with other immune checkpoint inhibitors, particularly PD-1/PD-L1 inhibitors. As a result, TIGIT inhibitors are being actively investigated across multiple solid tumors and hematological malignancies as a promising next-generation immuno-oncology strategy.

TIGIT Inhibitors Epidemiology Segmentation

The TIGIT inhibitors market report is a comprehensive and specialized analysis, offering in-depth epidemiological insights for the study period 2020–2034 across the leading markets. The TIGIT inhibitors target patient pool is segmented into:

Scope of the TIGIT Inhibitors Market Report

Discover emerging bispecific and combo therapies (TIGIT + PD-1 / PD-L1) @ TIGIT Inhibitors Clinical Trials

Table of Contents

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