Head-to-head Study Validates the Clinical Advantage of New-generation Biased GLP-1: Ecnoglutide Delivers 35% Greater Weight Loss than Semaglutide

NEW ORLEANS, June 7, 2026 /PRNewswire/ -- Hangzhou Sciwind Biosciences Co., Ltd. ("Sciwind Biosciences"), a commercial-stage biopharmaceutical company focused on discovering and developing innovative therapies for metabolic diseases, today announced that key data from a head-to-head study (SLIMMER-UP-SWITCH) evaluating ecnoglutide versus semaglutide was presented as a Late-Breaking abstract at the 86th Scientific Sessions of the American Diabetes Association (ADA) 2026. Interim analysis results showed that ecnoglutide, the world's first approved cAMP-biased GLP-1 receptor agonist, demonstrated greater weight loss compared to semaglutide, with a 35% greater reduction in body weight, a 20% greater reduction in waist circumference at Week 20, and nearly twice as many patients achieving ≥10% body weight loss.

Professor Linong Ji, Director of the Department of Endocrinology at Peking University People's Hospital, stated that this study provides the first direct clinical evidence validating the clinical advantages of the innovative cAMP-biased GLP-1 receptor agonist mechanism. By optimizing GLP-1 receptor signal transduction, it delivers superior clinical benefits over traditional GLP-1 receptor agonists, providing high-quality evidence-based medical evidence for the field of weight management.

Clear Weight Loss Advantage at Week 20: 35% Greater Mean Weight Reduction vs. Semaglutide, ≥10% Weight Loss Response Rate Nearly Twofold Higher

This study enrolled 163 adult patients with obesity (body mass index [BMI]≥30 kg/m²) across 17 research centers in China. Participants were randomized 1:1 to receive once-weekly subcutaneous injections of either ecnoglutide or semaglutide at the same maintenance dose of 2.4 mg¹.

Study data showed that at week 20, the least-squares mean percentage change in body weight from baseline was -12.8% in the ecnoglutide group and -9.5% in the semaglutide group (P...